NESA XSIGNAL® невромодулация в неврологията
NESA · Neurology & pain

Chronic pain has a non-invasive answer.

NESA modulates the autonomic nervous system in chronic pain, neuropathies and neurorehabilitation — with measurable improvement in sleep and cognitive function.

Information for healthcare professionals

Self-recognition

Do you recognise yourself?

Dysautonomia and autonomic balance

✓dizziness on standing
✓palpitations
✓severe fatigue
✓irregular digestion
✓unusual sweating
✓poor tolerance to exertion or heat
What happens in the autonomic nervous system

Like a miscalibrated control centre sending crossed signals. Dysautonomia is a direct imbalance between “gas” and “brake” — which is why symptoms shift from day to day.

Self-assessment, not self-diagnosis — discuss with a professional.

Why NESA in neurology

Structure and method for complex neurological processes.

01
01

Chronic pain

Reduced pain and a raised pain threshold without medication.

02
02

Sleep & cognition

Improved sleep quality and cognitive function — including in dementia.

03
03

Neurorehabilitation

Support of recovery in neurological injury and neuropathies.

Study results · neurology · dementia

In dementia, NESA improves sleep, reduces daytime sleepiness and raises cognitive function.

+49%
Sleep quality
−58%
Daytime sleepiness
+35%
Cognitive function

Source: Teruel-Hernández et al., IJERPH 2023 (dementia population). Individual results may vary. Information intended for healthcare professionals.

Clinical application

How NESA fits into neurological practice.

Mechanism

Low-frequency microcurrents (0.1–1 mA, 1–15 Hz), applied through the four limbs with a guiding electrode, engage the autonomic nervous system along its whole axis. Instead of suppressing a symptom, NESA restores the balance between the sympathetic and parasympathetic divisions — a state in which the brain consolidates sleep, modulates nociception and supports cognitive networks. That is why the effects accumulate across sessions and persist after the protocol, without habituation.

In neurology this is especially valuable where pain, disturbed sleep and autonomic dysregulation feed one another — in chronic and neuropathic pain, in dementia and in neurorehabilitation after injury.

Indications where it is applied
Chronic and neuropathic pain
Sleep disorders in neurological diseases
Dementia — sleep, daytime sleepiness, cognition
Neurorehabilitation after stroke or trauma
Polyneuropathies and autonomic dysfunction
How a session unfolds

The patient is at rest; electrodes are placed on the wrists and ankles and a guiding electrode according to the target. The session lasts ~55 minutes, painlessly. Standard protocol: 12–20 sessions, twice a week. The effect is monitored objectively through sleep and heart-rate variability.

Поставяне на електроди на крайниците с NESA XSIGNAL®
Across the four limbs

Microcurrents through the wrists and ankles — the whole autonomic axis at once.

For whom

Built for neurological practice.

Neurology clinics & wards

Pain, memory and sleep centres seeking a non-invasive complement.

Neurorehabilitation centres

Recovery after stroke, trauma and in polyneuropathies.

Geriatrics & dementia care

Improving sleep, daytime activity and cognition.

Downloadable materials

Full specialist presentation — neurology and pain.

Indications, protocols, programmes and clinical data for implementing NESA in your practice.

PDF Specialist presentationBulgarian · NESA · V2.1 ↓ PDF XSignal in Neurology — report (EN) ↓ PDFPatient cardFor patients · PDF (EN)↓
Frequently asked questions

Short answers for professionals.

Is the therapy safe?

Yes. NESA is a non-invasive, low-intensity method with no known systemic side effects. Sessions are conducted by a trained specialist.

Does it replace pain medication?

No. NESA complements pharmacological treatment and rehabilitation by reducing pain and improving sleep — often allowing the physician to review dosages.

When are the first results felt?

Many report better sleep after 4–6 sessions; the effect on pain and cognition builds over the full course.

Are there contraindications?

Pacemakers and other active electrical implants, pregnancy and epilepsy require prior medical assessment. When in doubt, consult the treating physician.

Related fields

Explore adjacent areas.

Protocol · 12–20 sessions · 2× weekly · 55 min

Add NESA to neurological care.

Request a demonstration →
Protocol parameters

Real values from the handbook (INF-CD-022)

Generalised pain and central sensitisation

Sessions~20
FrequencyInduction → maintenance
Duration60 min
ProgrammesP1 · P2 · P7 · P8
Guiding electrodeNasion · Sternum · Processus spinosus C6–C7
QuestionnairesWeCardio · Lattinen · LANSS

Visual disturbances in dysautonomia

Sessionsmin. 20 (up to 30–40)
FrequencyInduction → maintenance
Duration60 min
ProgrammesP1 · P2 · P7 · P8 · P9
Guiding electrodeSternum · C1–C2 · C6–C7
QuestionnairesWeCardio · GAD-7 · PSQI

Source: NESA protocol handbook · INF-CD-022 (2025-V.1). Standard session 60 min, LOW mode by default.

Therapeutic logic

At the core: programmes P1–P9

Every protocol in this field combines the reference programmes P1–P9 — general homeostasis, body levels, ANS/CNS and targeted nerves — according to the clinical goal.

See programmes P1–P9 →
Limits & safety

Protocols are guidelines.

·

Parameters are guides; the therapist adapts them to the patient.

·

NESA is applied after individual assessment — as part of the overall medical plan.

·

Absolute contraindications (pacemaker, pregnancy, active electrical implants) follow the device IFU.

Evidence to download

The clinical data as a shareable card.

The same numbers as above — in a ready-to-share format for colleagues, patients and social media.

Деменция — клинични данни Dementia Download ↓
INDEPENDENT CONSULTING

Before you invest — the independent assessment.

We map clinical goals, workflows, budget and reimbursement — then recommend the solution that meets the department’s needs, not the easiest to sell.

Assessment & selection →
Related topicAutonomic dysfunction after Long Covid — what science showsRead more →
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