FAQ · for professionals and patientsNESA XSIGNAL®

Clear answers on neuromodulation.

Short and honest: how NESA XSIGNAL® works, what it can and cannot do. This content is for information and does not replace a consultation with a professional.

Reference table

Programmes P1–P9

Each session combines one or several programmes according to the clinical goal. Below is the authoritative reference — function, guiding-electrode location and typical duration.

ProgrammeFunctionLocationDuration
P1Homeostasiscentral-cephalic15–45′
P2Body level · ventralventral15–30′
P3Body level · dorsaldorsal15–30′
P4Body level · sagittalsagittal15–30′
P5Resource optimiser15–60′
P6Analgesia15–60′
P7Autonomic nervous system (ANS)15–120′
P8Central nervous system (CNS)15–30′
P9Facial & trigeminal nervescranial15–120′

Standard session ≈ 60 minutes · LOW / HIGH modes by intensity · duration depends on the programme and clinical goal.

Guiding electrode

Three phases of targeting

Microcurrents are applied to the four limbs; the guiding (reference) electrode focuses the effect. Progression runs from general to specific.

01

Central

General regulation of the nervous system — the starting point of every protocol.

02

Metameric

Targeting at the segmental/metameric level according to the affected zone.

03

Focal

Targeted action on a specific structure or region.

Protocol frequency

From induction to maintenance

The therapeutic rhythm starts intensively and gradually thins out as regulation stabilises.

Induction phase
3–5× / week

Building the effect in the initial weeks.

Maintenance phase
1–2× / week

Stabilising the regulation achieved.

Assessment instruments

Measuring the outcome objectively

Progress is tracked with standardised questionnaires and scales — according to the protocol’s clinical goal.

PSQI
sleep quality
GAD-7
anxiety
VAS
pain intensity
LANSS
neuropathic pain
Borg
perceived exertion
Ashworth
spasticity
SF-36
quality of life
THI
tinnitus severity
DHI
dizziness & balance
EQ-5D
health status
01

Technical · how it works

What is NESA and how does it work technically?+

NESA is a system for non-invasive neuromodulation of the autonomic nervous system (ANS). It delivers very-low-frequency microcurrents (~1–15 Hz) through electrodes on the four limbs plus a guiding electrode, to support the balance between the sympathetic (“gas”) and parasympathetic (“brake”) systems.

Where are the electrodes placed?+

On the hands and feet — not on the affected organ. Through the limbs, the nervous system of the whole body is addressed, coordinating heart, vessels, lungs, digestion, hormones, immunity and eyes.

Are the currents painful?+

No. They are non-invasive, near-painless microcurrents of very low intensity; most people barely feel them.

02

Physiology · the nervous system

What is the autonomic nervous system (ANS)?+

The ANS governs unconscious functions — heart rate, breathing, digestion, vascular tone, hormones and immunity. It has two antagonists: the sympathetic (“gas”, activation) and the parasympathetic/vagus (“brake”, recovery).

What does the “gas–brake” image mean?+

It is the core everyday metaphor: many complaints arise when the “gas” (sympathetic) stays too high and the “brake” (vagus) is weak. NESA aims to support this balance.

What is the role of the vagus nerve?+

The vagus is the main parasympathetic “brake”. It is involved in regulating inflammation (cholinergic anti-inflammatory reflex), heart rhythm, digestive motility and immune balance.

03

Scientific basis

How should the state of the evidence be understood?+

The basis draws on research into ANS regulation, the vagal anti-inflammatory reflex and heart-rate variability (HRV) as a biomarker. For many NESA-specific applications the evidence is explicitly labelled “still preliminary”.

Do the studies prove a cure through NESA?+

No. The wording is supportive (“associated with”, “may contribute to”). NESA is presented as an accompaniment to the medical/therapeutic plan — not a replacement and not a cure.

What does “results vary individually” mean?+

The effect is not guaranteed and differs from person to person. This caveat is a permanent part of the communication.

04

Clinical application

Which fields have content?+

13 fields: neurophysiology, endocrinology, gastroenterology, pulmonology, rheumatology/immunity, vascular health, ophthalmology, preventive medicine, intimate health, rehabilitation/physiotherapy, speech therapy (adults and children) and psychology.

Does NESA replace existing treatment?+

No. NESA replaces neither medical/therapeutic treatment nor medication — it accompanies the existing plan (e.g. inhalers, biologics, physiotherapy, speech therapy, psychotherapy).

Who should supervise the application?+

Always a professional: depending on the field — a physician, physiotherapist (incl. pelvic floor), urologist/andrologist, gynaecologist, speech therapist or psychotherapist. It is applied under professional supervision.

05

For the patient

Will it hurt?+

No — the method is designed to be painless and non-invasive, without needles, using surface electrodes on hands and feet.

What can I realistically notice?+

Depending on the topic — more calm, better recovery and sleep, less tension, better tolerance to exertion. These are possibilities (“may help”), not a guarantee.

Are there contraindications?+

Yes. Do not use with a pacemaker or other active implants, or during pregnancy. When in doubt, ask the professional first. The full contraindications follow the official instructions for use (IFU).

06

Communication & training

How should NESA be talked about?+

Supportively and without promising a cure: “it modulates the autonomic nervous system — everything else follows from that”. Always with the caveat that NESA does not replace treatment and medication and that results vary.

What is the key idea?+

Electrodes on hands and feet (not on the organ) regulate the ANS of the whole body. NESA accompanies the professional’s plan; diagnosis, therapy and medication remain the basis.

Does the professional need training?+

Yes. Solid clinical training (NESA Academy/Campus) contributes substantially to clinical success — knowledge is the real technology.

Materials

Downloads

Official documents for deeper reading.

PDF · 79 pp. Patient reference Symptoms by field and the “gas–brake” mechanism. Download PDF →
INF-CD-022 Protocol handbook For medical professionals · available on request. On request
Important · limits & safety

Protocols are guidelines, not prescriptions.

·

Parameters (number of sessions, frequency, duration) are guides; the therapist adapts them to the patient.

·

NESA is not suitable for every patient and makes no promise of cure.

·

Absolute contraindications (pacemaker, pregnancy, active implants) follow the device instructions for use (IFU).

Application by specialty

See the programmes in the context of each field.